Lipoprotein (a) in ischemic heart disease and cerebrovascular disease.

نویسندگان

  • T Yamamura
  • S Nomura
  • X Yang
  • Y Toyota
  • M Sonobe
  • A Yamamoto
  • K Haze
  • K Hiramori
  • H Hara
  • T Yamaguchi
  • S N Pokrovsky
چکیده

Lipoprotein (a) [Lp(a)] was first described by Berg as a genetic variant of low density lipoprotein (LDL) more than twenty-five years ago (1). Lp(a) lipid composition is similar to that of LDL, and floats in a density range of 1.051.125g/ml. Its protein moiety contains a specific glycoprotein, apolipoprotein (a) [apo(a)], in addition to apo B-100. Recently, the cDNA sequence of human apo(a) was determined, and it shows a striking homology with plasminogen (2). This finding may provide a direct link between thrombogenesis and progressive atherosclerosis. We examined the association between Lp(a) concentrations and angiographically assessed atherosclerosis in coronary artery disease and cerebrovascular disease.

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عنوان ژورنال:
  • Journal of atherosclerosis and thrombosis

دوره 2 Suppl 1  شماره 

صفحات  -

تاریخ انتشار 1995